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Viewing posts from: July 2014


Posted by InformBioscience in News | 0 comments

Dublin 29 July 2014: Irish biotech startup, Inform Bioscience, has signed a license agreement with the world renowned Mayo Clinic (USA) to acquire a portfolio of biomarkers for use in developing a prognostic test to detect preeclampsia in pregnancy.

Prognostic tests provide advance indications of an illness or condition, and currently there are no such tests available to detect preeclampsia, a potentially fatal condition affecting pregnant women and their babies. Manifesting abruptly in late pregnancy, preeclampsia poses a serious threat to both mother and her unborn child. In the most severe cases it can progress to eclampsia which often results in seizure, stroke, coma and death. Presently, the disease is diagnosed by symptoms that are non-specific to preeclampsia and often exhibit when the condition is already full blown.

Discovered through pioneering research conducted by Vesna Garovic, M.D., at Mayo Clinic nephrologist, the biomarkers licensed by Inform Bioscience have the potential to detect preeclampsia much earlier than current methods. Inform Bioscience plans to develop a simple urine test, employing the biomarker technology, which has the potential to revolutionise prenatal care programmes globally.

“Our goal at Inform Bioscience is to develop non-invasive tests targeting unmet medical needs so that physicians can provide more personalised patient care. This license will allow Inform Bioscience to determine if a patient has preeclampsia from week 26 in pregnancy. We are very excited to have executed this licence and to be working towards ensuring better outcomes for mothers and babies globally,” said Charles Garvey, CEO Inform Bioscience.

“Inform Bioscience is bridging the gap between the discovery of quality technology and its commercialisation. Today is a key milestone in the development of Inform Bioscience and demonstrates our capacity to work with and integrate the work of world-class research institutions such as the Mayo Clinic and the BDI to bring innovative new technologies to market. We look forward to working closely with the Biomedical Diagnostics Institute at Dublin City University through an Enterprise Ireland-supported Innovation Partnership to advance the work of Dr. Garovic into commercialisation,” added Mr. Garvey.

“The Mayo Clinic and Enterprise Ireland recently formalised a collaboration which will see the commercialisation of up to 20 novel medical technologies in Ireland over the next 5 years, creating high value medical technology spin out companies. This latest licensing of technology by Inform Bioscience is in addition to this agreement, and shows the potential for Irish companies to develop commercialisation strategies as a result of these exciting innovations” said Dr.Keith O’Neill, Director of LifeSciences Commercialisation at Enterprise Ireland.

“The Biomedical Diagnostics Institute at DCU is excited by this opportunity to work with Mayo Clinic and Inform Bioscience. We strongly commend the initiative of Enterprise Ireland in facilitating and supporting this endeavour through its strategic collaboration with Mayo Clinic and look forward to working together to deliver this important new diagnostic test”, said Mr. Joseph McManus, Director BDI.

Inform Bioscience has secured seed round funding from AIB Seed Capital. The company is a subsidiary of Metabolomic Diagnostics, which is an innovative medical diagnostics company involved in the development of a breakthrough technology to provide early pregnancy risk stratification testing for preeclampsia. The technology being licensed by Inform Bioscience is very complementary to this technology.

* * * * ENDS * * * *

For more information, please contact:

Renate Murphy, CAMEO Communications
Tel: 021.4320067 Email: renate@cameo.ie

Notes to the Editor

About Preeclampsia: Preeclampsia affects 3 million mothers worldwide every year and is associated with premature births and infant illness including cerebral palsy, blindness, epilepsy, deafness and lung conditions. There is no effective detection method for the risk of preeclampsia and the cause is unknown. It is estimated that preeclampsia costs the global health care system US$3 billion per year.

About Inform Bioscience: Inform Bioscience is an indigenous Biosciences Company that has licenced innovative technology from Mayo Clinic to develop a prognostic test for preeclampsia. A high potential startup (HPSU) company it is supported by Enterprise Ireland. The company is based at Hoffman Industrial Park, Little Island, Cork. www.informbio.com

About Mayo Clinic: Recognizing 150 years of serving humanity in 2014, Mayo Clinic is a non-profit worldwide leader in medical care, research and education for people from all walks of life. 150years.mayoclinic.org, www.mayoclinic.org

About BDI: The Biomedical Diagnostics Institute (BDI) is an Academic-Business-Clinical partnership that carries out cutting-edge research into the development of next-generation biomedical diagnostic devices creating Point-of-Care solutions that will have a major impact on diagnosing disease and sustaining human health.

About DCU: Dublin City University (DCU) is a young, dynamic and ambitious university with a distinctive mission to transform lives and societies through education, research and innovation. Since admitting its first students in 1980, DCU has grown in both student numbers and size graduating over 43,000 students to date and now delivering more than 120 programmes to over 10,000 students across its four faculties – Humanities and Social Sciences, Science and Health, Engineering and Computing and DCU Business School. DCU is known as Irelands University of Enterprise recognised for the commercialisation of research and its engagement with national and international businesses.

About Enterprise Ireland: Enterprise Ireland is the Irish Government agency charged with developing and promoting Irish enterprise with the ultimate objective of increasing exports, employment and prosperity in Ireland. Enterprise Ireland partners with entrepreneurs, Irish businesses, and the research and investment communities to develop Ireland’s international trade, innovation, leadership and competitiveness.

Inform Bioscience to licence breakthrough technology from Mayo Clinic

Posted by InformBioscience in Links | 0 comments

Irish biotech start-up Inform Bioscience is to sign a licence agreement tomorrow with the world-renowned Mayo Clinic to acquire a portfolio of biomarkers for use in developing a test to detect pre-eclampsia in pregnancy. Read More

Taoiseach welcomes US$16M collaboration between Mayo Clinic and Enterprise Ireland

Posted by InformBioscience in News | 0 comments

A collaboration between Enterprise Ireland and Mayo Clinic, USA will see the commercialisation of up to 20 novel medical technologies in Ireland over the next 5 years with the aim of creating several high value medical technology spin-out companies. Read More

Advances in the pathophysiology of pre-eclampsia and related podocyte injury

Posted by InformBioscience in Links | 0 comments

Pre-eclampsia is a pregnancy-specific hypertensive disorder that may lead to serious maternal and fetal complications. It is a multisystem disease that is commonly, but not always, accompanied by proteinuria. Its cause(s) remain unknown, and delivery remains the only definitive treatment. It is increasingly recognized that many pathophysiological processes contribute to this syndrome, with different signaling pathways converging at the point of systemic endothelial dysfunction, hypertension, and proteinuria. Read More

Persistent Urinary Podocyte Loss following Preeclampsia May Reflect Subclinical Renal Injury

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Studies have shown that podocyturia, i.e., urinary loss of viable podocytes (glomerular epithelial cells), is associated with proteinuria in preeclampsia. We postulated that urinary podocyte loss may persist after preeclamptic pregnancies, thus resulting in renal injury. This may lead to future chronic renal injury. In addition, we compared the postpartum levels of the angiogenic factors, which previously have been associated with preeclampsia, between normotensive versus preeclamptic pregnancies. Read More

Podocytes and the Big Story

Posted by InformBioscience in Links | 0 comments

Currently there's no way to know for certain whether preeclampsia will develop during any given pregnancy. This leaves pregnant women and their care providers with little choice but to wait for symptoms to appear... dangerous symptoms that mean the disease has progressed to the point where mother and baby are critically ill and will need intensive monitoring and carefully timed delivery to protect their health and lives. The only screening method to date is to measure those symptoms when they appear. Read More

July 2014
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