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Inform Bioscience to licence breakthrough technology from Mayo Clinic

Posted by InformBioscience in Links | 0 comments

Irish biotech start-up Inform Bioscience is to sign a licence agreement tomorrow with the world-renowned Mayo Clinic to acquire a portfolio of biomarkers for use in developing a test to detect pre-eclampsia in pregnancy. Read More

Advances in the pathophysiology of pre-eclampsia and related podocyte injury

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Pre-eclampsia is a pregnancy-specific hypertensive disorder that may lead to serious maternal and fetal complications. It is a multisystem disease that is commonly, but not always, accompanied by proteinuria. Its cause(s) remain unknown, and delivery remains the only definitive treatment. It is increasingly recognized that many pathophysiological processes contribute to this syndrome, with different signaling pathways converging at the point of systemic endothelial dysfunction, hypertension, and proteinuria. Read More

Persistent Urinary Podocyte Loss following Preeclampsia May Reflect Subclinical Renal Injury

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Studies have shown that podocyturia, i.e., urinary loss of viable podocytes (glomerular epithelial cells), is associated with proteinuria in preeclampsia. We postulated that urinary podocyte loss may persist after preeclamptic pregnancies, thus resulting in renal injury. This may lead to future chronic renal injury. In addition, we compared the postpartum levels of the angiogenic factors, which previously have been associated with preeclampsia, between normotensive versus preeclamptic pregnancies. Read More

Podocytes and the Big Story

Posted by InformBioscience in Links | 0 comments

Currently there's no way to know for certain whether preeclampsia will develop during any given pregnancy. This leaves pregnant women and their care providers with little choice but to wait for symptoms to appear... dangerous symptoms that mean the disease has progressed to the point where mother and baby are critically ill and will need intensive monitoring and carefully timed delivery to protect their health and lives. The only screening method to date is to measure those symptoms when they appear. Read More

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